A common polymorphism in the ABCB11 gene encoding for the bile salt export pump is associated with advanced fibrosis in hepatitis C infection but not in fatty liver disease
R Iwata, B Stieger, AK Daly, JC Mertens, P Frei, J Braun, A Vergopoulos, IV Martin, O Goetze, CP Day, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: HCV-associated cirrhosis represents the main indication for liver transplantation in Western countries. Clinical factors influence the progression of fibrogenesis but cannot accurately predict the risk of cirrhosis. Bile acids (BA) contribute to hepatic stellate cell activation as a key event in fibrogenesis. Aim of this study was to investigate the role of BA and polymorphisms in BA level-regulating genes on fibrosis progression. Methods: 206 patients with chronic HCV infection from the Swiss Hepatitis C Cohort study were recruited for ABCB11(BSEP) 1331T>C and NR1H4(FXR) -1G>T genotyping. 178 patients wit…
