CareLit Fachartikel
A protective role of macrophage-migration inhibitory factor (MIF) in toxically induced liver fibrosis
D Heinrichs, M Jung, C Offermanns, ML Berres, J Bernhagen, HE Wasmuth · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
1168048
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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zitierfähig
Bibliografische Angaben
Zusammenfassung
Liver fibrosis is a wound healing response to chronic liver injury which is associated with excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cells (HSCs) are the main ECM-producing cells during liver fibrosis and have been considered to play a key role in this context. Owing to their potent chemotactic and immunoregulatory properties, chemokines contribute to the development of liver fibrosis. Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine, which has recently been recognized to function as a chemokine-like function (CLF) cytokine in chronic infl…
Schlagworte
MIF
cytokines
fibrosis
Cytokine
Chemokines
Chemokine
Address
Zeitschrift für Gastroenterologie
