CareLit Fachartikel

Endoglin is upregulated and counteracts profibrogenic responses in transdifferentiating hepatic stellate cells

SK Meurer, L Tihaa, R Weiskirchen · Zeitschrift für Gastroenterologie · 2010 · Heft 01

Dokument
1168049
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
SK Meurer, L Tihaa, R Weiskirchen
Ausgabe
Heft 01 / 2010
Seiten
–
Erschienen: 2010-01-12 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1246359

Zusammenfassung

Aims: The main cellular source of extracellular matrix (ECM) in the fibrotic liver are myofibroblast-like cells (MFB) originating from mesenchymal hepatic stellate cells (HSC). In the fibrotic processes of kidney (mesangial cells), heart (cardiac fibroblasts) and dermis (dermal fibroblasts) it has been shown that the accessory receptor endoglin is upregulated in the respective profibrogenic cells and modulates fibrosis relevant responses mediated by TGF-β1 [1–3]. In activated HSC, endoglin is also highly expressed but its functional relevance in TGF-β1-signaling has not been determined [4]. Methods and Results:…

Schlagworte

animal models endoglin fibrogenesis hepatic stellate cells signaling Connective Tissue Growth Factor Connective Tissue Arthritis Dermis Zeitschrift für Gastroenterologie