Bile Acid Transporters are differentially expressed in NAFLD patients and correlate with hepatocyte apoptosis
P Kocabayoglu, L Bechmann, A Kahraman, JP Sowa, M Schlattjan, G Kaiser, I Wedemeyer, A Paul, G Gerken, A Geier, AE Canbay · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Nonalcoholic fatty liver disease (NAFLD) at different stages of disease exhibits steatosis, inflammation and ballooning of hepatocytes and often occurs with fibrosis of the liver. Elevated bile acid levels and free fatty acids have recently been found in patients with steatohepatitis. In this study we investigated whether bile acids are upregulated and correlate with bile acid transporters, bile-acid-synthesis-enzyme Cyp7A1, apoptosis and fibrosis in NAFLD patients. Methodology: Blood and liver biopsies were taken from 49 consecutive morbidly obese patients who underwent bariatric surgery, were scored for…
