Chronic ethanol consumption promotes diethylnitrosamine-initiated hepatic carcinogenesis in rats
H Qin, PRG Chavez, G Millonig, F Lian, H Mernitz, P Bannasch, R Russell, S Mueller, H Bartsch, HK Seitz, XD Wang · Zeitschrift für Gastroenterologie · 2010 · Heft 01
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Zusammenfassung
Aims: Chronic and excessive alcohol consumption has been related to an increased risk of several cancers, including carcinoma (HCC); however, studies in animal models have yet to conclusively determine whether ethanol acts as a tumor promoter in HCC. We examined whether prolonged alcohol consumption alone could act as a hepatic tumor prompter after tumor initiation by low-dose diethylnitrosamine (DEN) in a rat model. Methods: Male Sprague-Dawley rats were injected with 20mg DEN/kg body weight one week before introduction of either an ethanol liquid diet or an isocaloric non-ethanol liquid diet. Hepatic histology…
