Patients with polycystic ovary syndrome expose elevated apoptosis indicating non-alcoholic steatohepatitis
S Tan, L Bechmann, S Benson, T Dietz, S Eichner, S Hahn, OE Janssen, H Lahner, G Gerken, K Mann, AE Canbay · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Patients with polycystic ovary syndrome (PCOS) often exhibit also obesity and insulin resistance (IR), two key features of non-alcoholic steatohepatitis (NASH). NASH is associated with cirrhosis and can culminate in hepatocellular carcinoma and liver failure. Recent studies successfully determined NASH via serum concentration of caspase 3-cleaved cytokeratin 18 (CK18) fragments (M30), resulting from apoptotic cell death. This study aimed to determine the prevalence of NASH in PCOS patients by M30 serum levels. Methods: In 192 PCOS patients (age: 29.0±6.7 years, BMI: 31.5±8.2kg/m2) as defined by AESPCOS cri…
