Differences in the source sequence of two HCV genotype 1b outbreaks within immunodominant CD8 epitopes are associated with differential outcome
S Giugliano, M Ruhl, C Neumann-Haefelin, M Wiese, R Thimme, M Roggendorf, U Spengler, J Nattermann, J Timm · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Distinct HLA-class I alleles have a differential impact on the outcome of HCV infection. In the Irish Anti-D cohort HLA-B27 was associated with spontaneous control and HLA-B8 with viral persistence. Although the protective effect of HLA-B27 was confirmed in other cohorts, discrepant results have been obtained for HLA-B8. The aim of this study is to determine the role of sequence differences in the source virus for the differential outcome associated with these alleles. Methods: Women from the East-German Anti-D outbreak were recruited 30 years after infection and the immunodominant B8-epitope (NS3-HSKKKCDE…
