Improved diagnostic accuracy of transient elastography for cirrhosis using histology plus clinics as gold standard
S Mueller, G Millonig, F Stickel, T Longerich, P Schirmacher, HK Seitz · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Measurement of liver stiffness (LS) by transient elastography (Fibroscan, FS) is a novel noninvasive approach to assess liver fibrosis with a high diagnostic accuracy. However, accuracy may be even higher since histology served as gold standard in all previous LS studies although its sample error may reach up to 30%. Consequently, we here determined the AUROC for FS to detect liver cirrhosis using a combination of histology and definite clinical signs of cirrhosis as obtained by ultrasound or gastroscopy in patients with alcoholic liver disease (ALD). Method: LS was measured in 90 patients with histologica…