1H-Spectroscopy at 7T in Prostate Cancer for Metabolite Detection to improve tumor characterization
CS Arteaga de Castro, UA van der Heide, PR Luijten, DWJ Klomp · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Purpose: Proton magnetic resonance spectroscopic imaging (1H-MRSI) has shown clinical potential in localizing and detecting tumor tissue that is reflected by the signal increase of choline and a signal decrease of citrates. This technique may facilitate individual diagnosis in order to improve therapy e.g. with radiotherapy dose painting. In addition, choline has been used as a marker for tumor recurrence enabling evaluation of radiotherapy response. However, the detection of choline is hampered by the limited spectral resolution obtained at 1.5 or 3T, causing choline to be overlapped with signals from polyamine…