CareLit Fachartikel

Mycobacteria-induced granuloma necrosis depends on IRF-1

S Aly, J Mages, N Reiling, U Kalinke, T Decker, R Lang, S Ehlers · Pneumologie · 2010 · Heft 01

Dokument
1168074
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
S Aly, J Mages, N Reiling, U Kalinke, T Decker, R Lang, S Ehlers
Ausgabe
Heft 01 / 2010
Seiten
–
Erschienen: 2010-01-20 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0029-1247899

Zusammenfassung

In a mouse model of mycobacteria-induced immunopathology, wildtype C57BL/6 (WT) and IFNαβ-receptor-KO mice developed circumscript, centrally necrotizing granulomatous lesions in response to aerosol infection with M. avium, whereas mice deficient in the IFN-γ-receptor, STAT-1 or IRF-1 did not exhibit granuloma necrosis. Comparative, microarray-based gene expression analysis in the lungs of infected WT, IFN-γ-KO and IRF-1-KO mice revealed four distinct clusters of genes with variable dependence on the presence of IFN-γ, IRF-1 or both. In particular, IRF-1 appeared to be directly involved in the differentiation of…

Schlagworte

Irf-1 Mycobacteria-Induced Granuloma Necrosis Immunopathology Response Infection Ifn-Γ Depends Mouse Model Wildtype Pneumologie