BETA-ADRENERGIC BLOCKADE OF THE SYMPATHETIC NERVOUS SYSTEM DECELERATES PERIPORTAL FIBROSIS IN ABCB4 KNOCKOUT MICE
I Strack, M Scheffler, E Konze, K Wendland, H Varnholt, S Schulte, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
BACKGROUND AND AIM: Hepatic Stellate Cells (HSC) express α- and β-adrenoceptors and adrenergic inhibition results in reduced collagen I and α-smooth muscle actin (SMA) expression. Therefore, HSC were suggested to be the main cellular targets of sympathetic inhibition by β-blockers in experimental sinusoidal fibrosis. In order to study the role of the sympathetic nervous system in liver fibrogenesis we used the Abcb4 knock-out model developing non-HSC based, periportal fibrosis, which mimics primary sclerosing cholangitis (PSC). Methods: Liver tissues of Abcb4 (-/-) mice untreated or treated with the β-adrenocept…
