Effect of X-irradiation on gene expression of rat liver chemokines: in vivo and in vitro studies
F Moriconi, H Christiansen, H Christiansen, N Sheikh, J Dudas, RM Hermann, RM Hermann, M Rave-Fränk, D Raddatz, B Saile, CF Hess, CF Hess, G Ramadori · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
PURPOSE: The liver is considered to be a radiosensitive organ. In fact, irradiation may lead to cirrhosis development. However inflammation was not observed in the rat liver after X-irradiation. As chemokine production is necessary for the recruitment of inflammatory cells in case of inflammation, aim of the study was to analyze the effect of X-irradiation on chemokine-gene-expression in rat liver and in isolated rat hepatocytes. METHODS AND MATERIALS: Rat livers and isolated rat hepatocytes were X-irradiated. RNA extracted from livers and from hepatocytes within the first 48 hours after irradiation was analyzed…
