The p53 family network induces apoptosis and chemosensitivity in hepatocellular carcinoma
AE Schulze Schleithoff, AF Koch, K Lorenz, G Melino, W Stremmel, PH Krammer, M Müller · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Mutation and/or inactivation of the p53 pathway is a common defect in hepatocellular carcinoma (HCC). There is mounting evidence that the p53-related genes p63 and p73 play an important role in human cancer. The discovery of p63 and p73 raised the possibility that they may be cancer-associated genes and as a consequence that p53 is not the only component in predicting prognosis and response to chemotherapy, but instead the status of the p53 family network. Methods: We investigated the mechanisms and the signaling pathways by which wild-type (wt) p53, transcriptional active p63 and p73 (TAp63, TAp73…
