Y-box protein–1/p18 fragment identifies malignancies in patients with chronic liver disease
F Tacke, N Kanig, E Yagmur, A En-Nia, CS Eberhardt, C Trautwein, PR Mertens · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & aims: Immunohistochemical detection of cold shock proteins is predictive for deleterious outcome in various malignant diseases. The active secretion of a family member, denoted Y-box (YB) protein–1, was recently discovered by our group. As effective screening tools for malignant diseases are warranted for high risk populations such as patients with liver cirrhosis considered for potential transplantation, we tested the clinical and diagnostic value of YB–1 protein fragment p18 (YB–1/p18) detection in blood for malignant and liver diseases in different cohorts of patients. Patients & methods: We used…