PD1 regulates alloreactive donor T cells after liver transplantation in graft-versus-host-disease
M Schuchmann, RG Meyer, S Gregor, E Distler, K Bender, E von Stebuth, C Huber, PR Galle, G Otto, W Herr · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction Graft versus host disease (GVHD) after liver transplantation (LTx) is a rare complication yet associated with a high mortality. Donor T cells, sited in high numbers in the liver graft are mediators of allo-reactivity. Recent studies suggest that allo-reactive T cells are regulated by CD4/CD25/FoxP3-positive regulatory T cells (Tregs). Here, we provide evidence of an alternative regulatory pathway involving the membrane receptor Programmed Death–1 (PD1). Methods and Results At postoperative day 35 (POD 35) after liver transplantation for alcoholic liver cirrhosis, our patient presented with acute GVH…
