CareLit Fachartikel

CCL5 expression in peripheral blood as a surrogate marker for the stage of fibrosis in patients with chronic hepatitis C

A Katsounas, B Wang, M Trippler, J Schlaak · Zeitschrift für Gastroenterologie · 2008 · Heft 01

Dokument
1168241
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Katsounas, B Wang, M Trippler, J Schlaak
Ausgabe
Heft 01 / 2008
Seiten
–
Erschienen: 2008-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2008-1037609

Zusammenfassung

Aims: Recent data suggested that CCL5 (RANTES) may play an important role in liver fibrosis as its expression is upregulated in the liver of patients with cirrhosis. Therefore, we have studied its expression in the peripheral blood of patients with chronic hepatitis C and its modulation by antiviral therapy with IFN-α in vivo. Materials and methods: A total of 36 Caucasian patients with histologically proven chronic hepatitis C were treated with standard combination therapy consisting of (A: ) pegylated IFN-α2a (Pegasys, 180µg once weekly, n=21) for 12 months (HCV genotype 1, n=19) or 6 months (HCV genotype 3a,…

Schlagworte

CCL5 HCV liver fibrosis Blood Hepatitis After Zeitschrift für Gastroenterologie