CareLit Fachartikel

Analysis of a functional promoter polymorphism of the MCP–1 gene in patients with spontaneous bacterial peritonitis

E Gäbele, M Mühlbauer, H Paulo, H Paulp, M Johann, C Melzer, R Wiest, N Wodarz, J Schölmerich, C Hellerbrand · Zeitschrift für Gastroenterologie · 2008 · Heft 01

Dokument
1168247
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
E Gäbele, M Mühlbauer, H Paulo, H Paulp, M Johann, C Melzer, R Wiest, N Wodarz, J Schölmerich, C Hellerbrand
Ausgabe
Heft 01 / 2008
Seiten
–
Erschienen: 2008-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2008-1037669

Zusammenfassung

Spontaneous bacterial peritonitis (SBP) is a bacterial infection of ascitic fluid in patients with decompensated cirrhosis. Factors influencing the development of SBP are poorly understood but clinical and experimental data suggest that peritoneal macrophages contribute to the control of SBP. MCP–1 is a potent chemokine and a functional polymorphism in the promoter region of the MCP–1 gene (A–2518G) was found to confer increased MCP–1 expression. Here, we investigated this polymorphism in patients with SBP. Methods: MCP–1 genotyping was performed in 26 patients with SBP and 67 cirrhotic control patients with non…

Schlagworte

Ascites Allele Ascitic Fluid Chemokine Zeitschrift für Gastroenterologie