EEG-vigilance regulation: BOLD signal correlations and pathological aspects in psychiatric disorders

Different global functional states of the brain can be separated with electroencephalogram (EEG) not only during sleep (sleep stages 1, 2, 3, NREM and REM sleep) but also during wakefulness under resting conditions (EEG-vigilance stages from full alertness to sleep onset). The development of a computer based algorithm enables a more reliable classification of these EEG-vigilance stages than a visual inspection of EEG data does. These EEG-vigilance stages were used as regressors for the analysis of simultaneous functional magnetic reso-nance imaging (fMRI) and EEG measurements in healthy controls. It has been fou…