CareLit Fachartikel

Cadmium toxicity in a bronchial co-culture model

C Pohl, I Hermanns, M Bock, K Kehe, C Kirkpatrick · Pneumologie · 2008 · Heft 04

Dokument
1168541
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
C Pohl, I Hermanns, M Bock, K Kehe, C Kirkpatrick
Ausgabe
Heft 04 / 2008
Seiten
–
Erschienen: 2008-04-07 00:00:00
ISSN
0934-8387
DOI
10.1055/s-2008-1074129

Zusammenfassung

Cadmium is an industrial and environmental pollutant which can damage depending on the dose and route of exposure various organs including the lung. After an explant-outgrowth culture of epithelial cells from small bronchi pure populations of primary isolated normal human bronchial epithelial cells (NHBE) were cultured with lung fibroblasts as bilayer on a 24-well HTS-Transwell filter plate. The cells were grown on a collagen type I and maintained at an air-liquid interface (ALI) by feeding basolaterally with medium. Barrier properties and morphological phenotype were compared over 31 days. The NHBE formed confl…

Schlagworte

Cadmium Calcium After Cytokines Cytokine Bronchi Pneumologie