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Nanohale – Cytotoxic and proinflammatory evaluation of various PEI particles on lung target cells

A Beyerle, O Merkel, H Schulz, T Kissel, T Stöger · Pneumologie · 2008 · Heft 04

Dokument
1168555
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
A Beyerle, O Merkel, H Schulz, T Kissel, T Stöger
Ausgabe
Heft 04 / 2008
Seiten
–
Erschienen: 2008-04-07 00:00:00
ISSN
0934-8387
DOI
10.1055/s-2008-1074269

Zusammenfassung

Various polyethylenimines (PEI) of different molecular weights and surface modifications have been described for DNA and siRNA gene delivery. However, their safety profile remains of major importance. For this reason a broad range of different modified PEI particles have been developed to reduce cytotoxicity. Promising approaches are: (i) PEI particles with low molecular weight, and (ii) surface modifications of the highly positive charged PEI-particle with nonionic, hydrophilic polymers such as polyethylene glycol (PEG). For our project, we focus on inhalative applications of such PEI particles and their most i…

Schlagworte

Particles Their Different Molecular Cytotoxicity Modifications Weight Investigated Proinflammatory Various Target Cells Pneumologie