Relationship between pro-inflammatory Interferon-γ level and disease severity in pericardial tuberculosis
J Wolske, K van Veen, F Seyed, J Russell, K Tibazarwa, N Ntsekhe, B Mayosi, R Wilkinson, K Wilkinson · Pneumologie · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Objective: Tuberculous pericarditis accounts for 60% of all cases of pericarditis in Africa. We aimed to correlate pericardial disease severity with cytokine expression from blood and pericardial fluid in patients with tuberculous pericarditis. Methods: 44 patients presenting with tuberculous pericardial effusions (PE) were prospectively recruited in Cape Town, Rep South Africa. Enzyme-linked immunosorbent assays were performed on PE and serum samples for the following cytokines: TNF, IFN-γ, IL-10, IL-1β, and TGF-β. Correlations were ascertained between PE and serum cytokine levels and clinical data indicative o…
