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Der Leu72Met-Polymorphismus des Ghrelin-Gens vermindert das Risiko für Diabetes mellitus Typ 2 aber erhöht das Risiko für atherosklerotische Erkrankungen

E Giannakidou, HK Berthold, W Krone, I Gouni-Berthold · Diabetologie und Stoffwechsel · 2008 · Heft 04

Dokument
1168613
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
E Giannakidou, HK Berthold, W Krone, I Gouni-Berthold
Ausgabe
Heft 04 / 2008
Seiten
–
Erschienen: 2008-04-18 00:00:00
ISSN
1861-9002
DOI
10.1055/s-2008-1076209

Zusammenfassung

Background and purpose of the study: Ghrelin is a gut-brain regulatory peptide involved in the control of appetite and energy balance. The Leu72Met polymorphism of the ghrelin gene has been associated with the modulation of glucose tolerance and body fat composition. There are contradictory data regarding its association with the development of Diabetes mellitus type 2 (DM2). Purpose of the present study was to examine whether the Leu72Met polymorphism is associated with DM2 in a German population and whether it is associated with the presence of atherosclerosis. Methods: We investigated 420 subjects with DM2 (5…

Schlagworte

Atherosclerosis Association Diabetes Mellitus Population Allele Type 2 Typ 2 Angina Pectoris Blood Pressure Physicians Appetite Database Blood Diabetologie und Stoffwechsel