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Imprinting influences gene expression but not type 1 diabetes development of BB rats

I Klöting, P Lutze, R Baguhl, B Wilke · Diabetologie und Stoffwechsel · 2008 · Heft 04

Dokument
1168634
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Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
I Klöting, P Lutze, R Baguhl, B Wilke
Ausgabe
Heft 04 / 2008
Seiten
–
Erschienen: 2008-04-18 00:00:00
ISSN
1861-9002
DOI
10.1055/s-2008-1076419

Zusammenfassung

Aim: To prove the relevance of imprinting in type 1 diabetes development of BB rats the diabetogenic gene, Iddm4, located in an imprinted region on rat chromosome 6q32, a male and female segment of SHR chromosome 6 (D6Rat66-D6Rat3) was introgressed into the BB/OK background termed briefly BB.6Sm(ale) and BB.6Sf(emale). These congenic BB.6S rats were characterized for diabetes occurrence and gene expression profile. Materials and methods: Fifty two BB.6Sm, 50 BB.6Sf rats and 44 BB/OK rats were characterized for diabetes occurrence up to an age of 30 weeks. The expression of 8 genes located in or around the imprin…

Schlagworte

Diabetes Expression Genes Mirnas Between Development Imprinted Congenic Imprinting Chromosome Significantly Different Diabetologie und Stoffwechsel