Targeted disruption of Slc2a8 (GLUT8) reduces ATP levels and mitochondrial potential of spermatozoa
V Gawlik, S Schmidt, A Scheepers, G Wennemuth, R Augustin, M Moser, H Al-Hasani, HG Joost, A Schürmann · Diabetologie und Stoffwechsel · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: GLUT8 is a class 3 sugar transport facilitator, and transports glucose with high affinity (Km ˜2mM). GLUT8 mRNA is expressed in brain, heart, skeletal muscle, adipose tissue, adrenal gland, liver and at particulary high levels in testis. In testis, the GLUT8 protein is located in an intracellular compartment of spermatocytes, spermatids and mature spermatozoa. GLUT8 contains an N-terminal dileucine sorting signal retaining the transporter in an intracellular compartment. So far a stimulus inducing translocation of the transporter to the plasma membrane has not been found. Therefore, a function for GLUT8 in…
