Investigation of Na+/H+ exchanger activity in normal and inflamed human colonic epithelial cells
K Farkas, Z Rakonczay Jr, F Nagy, T Molnár, Z Szepes, L Varga, A Schnúr, N Legány, T Takács, T Wittmann, U Seidler, P Hegyi · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
It has been shown in animal studies that Na+/H+ exchangers (NHEs) influence the activities of the inflammatory process in IBD; inhibition of NHE activity with amiloride decreased disease activity in mouse dextran sulfate model of IBD. There are only scarce available data on the NHE activities of the normal and inflamed human colon. The aim of this study was to examine the activities of NHE1–3 in normal and inflamed (ulcerative colitis [UC] and Crohn's disease [CD]) human colonic epithelial cells along the whole large intestine and in different parts of the colonic crypts. Methods. Colonic biopsies were obtained…
