CareLit Fachartikel
The role of central endogenous opioid system in the regulation of gastric mucosal integrity
Z Zádori, N Shujaa, A Rónai, K Gyires · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Dokument
1168799
CareLit-ID
Jahr
2008
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background: The entire pathogenesis of peptic ulcers has not been clarified yet. Besides the essential role of hydrochloric acid and pepsin impairment of mucosal defensive factors also plays an important role in the development of ulcer disease. Augmentation of mucosal resistance can be induced through both peripheral and central mechanisms. Several neuropeptides, e.g. TRH or amylin have been demonstrated to induce gastroprotection after central administration. Our previous results indicated that activation of central α2-adrenoceptors induces gastroprotective effect and opioid component (namely β-endorphin) was…
Schlagworte
After
Hydrochloric Acid
Work
Aminopeptidase
Amylin
Zeitschrift für Gastroenterologie
