Impact of a haplotype (Val66Met) in the brain derived neurotrophic factor (BDNF) gene on serotonergic neurotransmission as reflected by the loudness dependence of auditory evoked…
C Norra, C Schumacher, I Giegling, H Assion, P Mavrogiorgou, O Pogarell, C Mulert, U Hegerl, D Rujescu, G Juckel · Klinische Neurophysiologie · 2010 · Heft 03
Bibliografische Angaben
Zusammenfassung
Objectives: The serotonergic system plays an important pathophysiological role in various psychiatric disorders. Brain derived neurotrophic factor (BDNF) is involved in the differentiation and survival of serotonergic neurons. A previous study showed that low serum BDNF levels were associated with strong loudness dependence of auditory evoked potentials (LDAEP) as a reflection of low central nervous serotonergic activity. To evaluate the genetic basis of this relationship, we studied whether the LDAEP is correlated with genetic variants within the BDNF gene. Methods: Auditory evoked potentials (AEP) of 95 health…
