Reduced fractional anisotropy in the Substantia Nigra in Patients with Parkinson's disease as a sign for fiber track degeneration

Introduction: Based on several studies, some authors assume high-resolution diffusion tensor imaging of the substantia nigra (SN) in patients with Parkinson's disease (PD) as a possible non-invasive bio marker for the presence of a Morbus Parkinson. The goal of this study is therefore to evaluate and optimise existing procedures. Methods: 7 patients with PD following the Unified Parkinson Disease Rating Scale (UPDRS) and 7 healthy, age-matched subjects received 3 Tesla high resolution diffusion tensor imaging of the substantia nigra with different examination protocolls. 3 ROIs on each side of the SN were applie…