Acarbose treatment enhances levels of midregional-pro-atrial-natriuretic peptide: Evidences for gut-heart-axis?
N Rudovich, A Ernst, MO Weickert, O Pivovarova, AM Arafat, NG Morgenthaler, A Bergmann, AFH Pfeiffer · Diabetologie und Stoffwechsel · 2010 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: Acarbose unexpectedly reduced blood pressure and especially new cases of hypertension in the STOP-NIDDM study. Atrial natriuretic peptide (ANP) is a potent natriuretic and vasorelaxant hormone that is secreted mainly by cardiomyocytes and plays contributory roles in cardiovascular homeostasis. In the subjects with Metabolic Syndrome (MS) circulating level of N-terminal natriuretic peptides are decreased for unknown reason. The midregional-pro-atrial-natriuretic peptide (MR-proANP) is a stabile fragment of the ANP precursor proANP, which is co-secreted with mature ANP from cardiomyocytes. We hypothesized th…
