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SGK1– a novel prognostic marker & potential drug target in medulloblastoma

S Pleier, D Sturm, M Remke, H Witt, V Goidts, G Reifenberger, J Felsberg, A Kulozik, A Korshunov, P Lichter, S Pfister · Klinische Pädiatrie · 2010 · Heft 05

Dokument
1169229
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Jahr
2010
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
S Pleier, D Sturm, M Remke, H Witt, V Goidts, G Reifenberger, J Felsberg, A Kulozik, A Korshunov, P Lichter, S Pfister
Ausgabe
Heft 05 / 2010
Seiten
–
Erschienen: 2010-05-07 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0030-1254479

Zusammenfassung

Medulloblastoma comprises the most common malignant brain tumour in children. We performed array-CGH (n=120), genome-wide mRNA expression profiling (n=60) and immunohistochemistry (n=210) and correlated the results to clinical data. The genomic locus of Serum- and glucocorticoid-inducible kinase (SGK1) at 6q23 was frequently targeted by DNA copy-number gain in high-risk medulloblastoma, and elevated SGK1 mRNA and protein levels were highly associated with poor overall survival (p

Schlagworte

Apoptosis Biology After Dexamethasone Tumor Klinische Pädiatrie