CareLit Fachartikel
Systems genetics of liver fibrogenesis in a murine reference population: Association mapping and pair scans in BXD recombinant inbred lines
R Hall, R Muellenbach, K Hochrath, S Weber, K Schughart, F Lammert · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Dokument
1169549
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Jahr
2010
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Zusammenfassung
Aims: Complex phenotypes are not only due to single locus variation, but are influenced by environmental covariates as well as epistatic interactions. Association mapping is based on phenotypic variations between inbred strains to identify genetic determinants of complex traits. Within the framework of the German Network of Systems Genetics (GeNeSys), we are investigating the BXD panel of recombinant inbred lines, which were generated by intercrossing C57BL/6J and DBA/2J mice, in a systems genetics approach to identify genetic loci and loci interactions that confer susceptibility to liver fibrosis. Methods: In t…
Schlagworte
Association
Chromosomes
Population
Alleles
After
Zeitschrift für Gastroenterologie
