The plasma lipidomic signature of Abcb4–/– mice with secondary biliary fibrosis
K Hochrath, J Adamski, C Prehn, J Henrichs, B Rathkolb, K Micklich, H Fuchs, V Gailus-Durner, M Hrabé de Angelis, F Lammert · Zeitschrift für Gastroenterologie · 2010 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: The ABCB4 (ATP binding cassette transporter 4) gene encodes the hepatobiliary phosphatidylcholine transporter. Abcb4 knockout in mice results in secondary biliary fibrosis. Nevertheless, the miscellaneous impact of ABCB4 deficiency on lipid homeostasis has yet to be defined. Our aim now was to perform a comprehensive analysis of lipid metabolites, including phosphatidylcholine (PC) and sphingomyelin molecular species, in plasma of Abcb4 –/– mice and wild-type controls. Material & methods: We collected plasma samples from Abcb4 –/– knockout mice with two different genetic backgrounds (BALB/cJ, FVB/NJ; 10 mi…
