CareLit Fachartikel
Mouse model for HBV-associated liver fibrosis
Y Churin, M Roderfeld, D Glebe, E Roeb · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1169807
CareLit-ID
Jahr
2011
Publikation
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Chronic hepatitis B virus (HBV) infection is associated with acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Here we analysed transgenic mice (Tg) that overproduce the HBV large envelope polypeptide. This model allows studying liver disease that mimics many of the pathological events in humans upon HBV infection1. The aim of this study was to compare the development of HBV envelope polypeptides-induced hepatic fibrosis in Tg on two different genetic backgrounds. Methods: Tg (C57BL/6 versus BALB/c) producing HBV large envelope polypeptide and hepatitis B surface antigen (HBsAg) in the liver…
Schlagworte
Hepatitis
Alanine Transaminase
Alanine
Actin
After
Zeitschrift für Gastroenterologie
