CareLit Fachartikel
Alcohol and a high-fat diet synergistically induce hepatic inflammation and fibrosis via TLR4
E Gäbele, K Dostert, C Dorn, F Stickel, C Hellerbrand · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1169808
CareLit-ID
Jahr
2011
Publikation
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Metadaten
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ja
zitierfähig
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Zusammenfassung
Aims: Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are the most frequent conditions leading to elevated liver enzymes and liver cirrhosis in the Western World. However and despite strong epidemiological evidence for combined effects on the progression of liver injury the mutual interaction of the pathophysiological mechanisms is incompletely understood. The aim of this study was to establish and analyze an experimental murine model, where we combined chronic alcohol administration in drinking water (increasing concentrations up to 5%) with a NASH inducing high-fat (HF) diet for six we…
Schlagworte
ASH
Fibrosis
NASH
TLR4
synergism
Diet
Zeitschrift für Gastroenterologie
