TRAIL and TNFR1-dependent pathways and their role for progression of Nemo-dependent hepatitis
A Singh, FJ Cubero, E Borkham-Kamphorst, M Al-Masaoudi, C Liedtke, T Luedde, R Weiskirchen, M Heikenwälder,, C Trautwein · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatocyte-specific NEMO knockout mice (NemoΔhepa) show that the IκB kinase subunit NEMO/IKKγ is essential for activating the transcription factor NF-κB, which regulates cellular responses during inflammation, cell proliferation and apoptosis. Therefore we aimed to better characterise the protective pathways in death receptor-mediated hepatocyte apoptosis in NemoΔhepa animals. We generated NemoΔhepaTRAIL-/-, NemoΔhepaTNFR1-/- and NemoΔhepaTRAIL-/-TNFR1-/- animals and analyzed the consequences compared to NemoΔhepa animals. NemoΔhepaTRAIL-/- like NemoΔhepa mice developed a phenotype characterized by apoptosis, pr…
