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The HDAC inhibitor Panobinostat induce differentiation and reduce de-differentiation in human hepatoma xenografts

B Alinger, P Di Fazio, K Quint, M Ocker, D Neureiter · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1169813
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
B Alinger, P Di Fazio, K Quint, M Ocker, D Neureiter
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269519

Zusammenfassung

Aims: Beside proliferation and apoptosis the status of trans- or de-differentiation seems to play a key role in tumor initiation, progression or metastasizing. Inhibitors of histone deacetylases (HDACi) represent a novel therapeutic option for human cancer diseases. The aim of this study is to show the possible influence of epigenetic modifications on the differentiation mechanisms of human hepatocellular carcinoma (HCC) cell line xenografts. Materials and Methods: Human HCC cell line HepG2 was implanted subcutaneously (5×106 cells) in male NMRI mice. The pan-HDACi Panobinostat (LBH589) was applied in a dose of…

Schlagworte

epigenetics hepatocellular carcinoma trans- and de-differentiation Apoptosis Tumor Zeitschrift für Gastroenterologie