Activation of the SKP2 protooncogene is a common effector pathway in hepatocarcinogenesis and contributes to malignant transformation of the liver
DF Calvisi, X Chen, C Ho, S Ladu, S Mattu, G Destefanis, S Delogu, F Dombrowski, M Evert · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
We have recently shown that upregulation of SKP2 protooncogene is associated with the development and progression of human hepatocellular carcinoma (HCC). In the present study, we further investigated the functional role of SKP2 by using in vitro and in vivo approaches. Forced overexpression of a number of known liver oncogenes, including AKT, E2F1, N-Ras, ERK2, STAT5b, and mutated beta-catenin in human HCC cell lines led to increased proliferation, which was associated with the rise in the levels and activation of SKP2 (as assessed by SKP2-mediated degradation of p27, p57, and p130 target genes). Although the p…
