CareLit Fachartikel
Oncogenetic tree modeling of human hepatocarcinogenesis
T Longerich, MM Müller, K Breuhahn, P Schirmacher, A Benner, C Heiß · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1169818
CareLit-ID
Jahr
2011
Publikation
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Metadaten
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Zusammenfassung
Classical Comparative Genomic Hybridization (CGH) has been used to identify recurrent genomic alterations in human HCC. Since hepatocarcinogenesis is considered a step-wise process, we applied oncogenetic tree modeling on all currently available classical CGH data to determine occurrence of genetic alterations over time. Nine losses (1p, 4q, 6q, 8p, 9p, 13q, 16p, 16q, 17p) and ten gains (1q, 5p, 6p, 7p, 7q, 8q, 17q, 20p, 20q, Xq) of genomic information were detected in more than 10% of cases and were selected to build the oncogenetic tree model. Whereas gains of 1q and 8q together with losses of 8p formed a clus…
Schlagworte
hepatocellular carcinoma
chromosomal instability
oncomodel
Tumor
Association
Biomarkers
Diagnosis
Zeitschrift für Gastroenterologie
