CareLit Fachartikel
Characterisation of Adult Liver Derived Progenitor Cells (ALDPC) and use for cell therapy and in vitro drug testing
M Bock, M Rothe, U Rüdrich, G Riedel, S Kirsch, M Iken, M Ott, MP Manns · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1169823
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Primary hepatocytes rapidly dedifferentiate in tissue culture and thus can be used for research purposes only for approximately 2 days.However, upon long term culture of primary hepatocytes (plate-and-wait method, [1,2]) a unique population of cells appears, we dubbed them Adult Liver Progenitor Cells (ALDPC) and are meanwhile able to generate them on a standardised basis from murine and human samples.ALDPC have a liver cell progenitor phenotype, i.e. depending on culture conditions they develop hepatic resp. cholangiocytic characteristics. Futhermore, the cells proliferate in tissue culture without obvious sign…
Schlagworte
cell therapy
drug screening
hepatocyte progenitors
maturation
proliferation
qPCR
Population
Aging
After
Transplantation
Zeitschrift für Gastroenterologie
