CareLit Fachartikel

Molecular mimicry rather than identity breaks T cell tolerance in a mouse model for autoimmune hepatitis

J Ehser, M Holdener, E Hintermann, U Christen · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1169828
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Ehser, M Holdener, E Hintermann, U Christen
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269669

Zusammenfassung

The etiology of autoimmune hepatitis (AIH) is poorly understood although the major autoantigen, cytochrome P450 2D6 (CYP2D6), has been identified and immunodominant epitopes mapped. We generated a mouse model for AIH using the natural human autoantigen CYP2D6 as a triggering molecule. Wildtype FVB mice infected with an adenovirus expressing the human CYP2D6 (Ad-2D6) to break self-tolerance to the mouse CYP2D6 homologues (molecular mimicry) showed persistent features characteristic for liver damage associated with AIH (fibrosis, ‘fused’ lobules, cellular infiltrations and necrosis). Ad-2D6-infected mice generated…

Schlagworte

CYP2D6 epitope mapping Antibodies Autoimmune Hepatitis Hepatitis Cytochrome Zeitschrift für Gastroenterologie