CareLit Fachartikel
Influence of a genetic variant in the Duffy Antigen Receptor for Chemokines (DARC) on chronic liver diseases
F Grünhage, S Weber, M Mahler, F Lammert · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1169829
CareLit-ID
Jahr
2011
Publikation
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Zusammenfassung
Introduction: Recently, the scavenger receptor DARC receptor variant Asp42Gly was identified in a genome wide association scan to be associated with monocyte chemotactic protein 1in healthy individuals (Schnabel et al. Blood 2009). We now hypothesised that this DARC variant may be associated with susceptibility to chronic hepatitis C virus (HCV) infection and liver stiffness. Patients and methods: Overall, 885 patients were included in the study. Most of the patients (N=520) were anti-HCV positive (+); 365 non-infected patients suffered from other chronic liver diseases. Liver fibrosis was assessed by transient…
Schlagworte
Association
Allele
Chemokines
Blood
Hepatitis
Zeitschrift für Gastroenterologie
