Bile proteomic profiles differentiates cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis
T Lankisch, J Metzger, A Negm, K Vosskuhl, E Schiffer, K Thedieck, A Schneider, R Baumeister, MP Manns, H Mischak, J Wedemeyer · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Early detection of malignant biliary tract diseases, especially cholangiocarcinoma (CC) in patients with primary sclerosing cholangitis (PSC), is very difficult and often comes too late to give the patient a therapeutic benefit. We hypothesize that bile proteomic analysis distinguishes CC from non-malignant lesions. Methods: We used capillary electrophoresis mass spectrometry (CE-MS) to identify disease specific peptide patterns in patients with choledocholithiasis (n=16), PSC (n=18) and CC (n=16) in a training set. A model for differentiation of choledocholithiasis from PSC and CC (PSC/CC model) a…
