CareLit Fachartikel
Targeting Epigenetic Maintenance of Stemness in Pediatric Malignancy
S Burdach · Klinische Pädiatrie · 2010 · Heft 12
Dokument
1169873
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
A shift of the focus in cancer research from genetic to epigenetic mechanisms can be observed during the last five years. Chromatin modifications are increasingly recognized as a key mechanism. The histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) is the enzymatic subunit of the polycomb PRC2 complex and methylates histone H3K27, thereby, mediating gene silencing. EZH2 is over-expressed in a variety of tumor tissue including breast and prostate. Ewing Tumors (ET), are highly malignant tumors that are molecularly defined by ews/ets translocations, with fli1 being the ets family member mos…
Schlagworte
Tumor
Acetylation
Chromatin
Biology
Breast
Klinische Pädiatrie
