Terguride attenuates myocardial remodelling and diastolic dysfunction in the pressure overloaded right heart
DR Krompiec, W Janssen, S Savai Pullamsetti, Y Schymura, H Luitel, HA Ghofrani, N Weissmann, F Grimminger, R Reiter, W Seeger, RT Schermuly · Pneumologie · 2011 · Heft 03
Bibliografische Angaben
Zusammenfassung
Rationale: Sustained right ventricular (RV) pressure overload causes myocardial remodelling and heart failure. However, little is known about the role of serotonin (5-hydroxytryptamine, 5-HT) and its receptors in RV hypertrophy due to RV pressure overload. We therefore investigated the effects of the 5-HT2a- and 5-HT2b-receptor antagonist terguride on myocardial hypertrophy and fibrosis, as well as diastolic function in RV pressure overload. Methods: Pulmonary artery banding (PAB) was applied to male C57Bl6N-mice with a hemoclip to an outer diameter of 0.35mm. Sham mice underwent the same procedure except for PA…
