Characterization of Experimental Gliomas by Multi-Modal Molecular Imaging

Background: Molecular imaging allows the non-invasive longitudinal characterization of disease specific alterations in vivo not only in experimental models but also in humans. This technology is increasingly used for assessing cancer-associated molecular markers as the basis for implementation of disease-stage specific therapies. Aim: The goal of this study was to assess the growth dynamics of human gliomas in a mouse model by multi-modal imaging. Methods: Imaging of subcutaneous and intracranial growing and stably luciferase (LUC) expressing human U87 and Gli36 gliomas in nude mice (n=27) was performed employin…