Expression of the kinocilia marker gene WDR16: An indicator of favourable prognosis in pediatric ependymoma

Introduction: Intracranial ependymoma comprises the second most common malignant brain tumor in childhood. The prognosis of intracranial ependymoma remains generally poor and its biological behavior is unpredictable based on current staging approaches. Recently, the first molecular risk stratification model based on cytogenetic aberrations was published by our group (Korshunov et al. 2010). Nevertheless, the identification of additional robust molecular biomarkers, which would help to stratify patients and are readily available to routine application are desperately needed. Method: We performed genome-wide mRNA…