The application of the net-benefit approach in cost-effectiveness analysis of polypharmacy in the treatment of schizophrenia under real world treatment conditions

Background/Objectives: Health economic analyses of data from observational trials are difficult because conventional methods of cost-effectiveness analyses do not allow the application of multivariate statistical methods for the correction of the selection bias. In this study, the cost-effectiveness of antipsychotic polypharmacy in comparison to monotherapy in schizophrenia treatment will be analysed under routine psychiatric care conditions. Methods: 374 patients with schizophrenia or schizoaffective disorders who received a recommendation for maintenance treatment with a second generation antipsychotic were in…