CareLit Fachartikel
Distinct regulation of adaptive and innate immune responses by Candida albicans
L Werner, B Wächtler, B Hube, A Sturm · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Dokument
1170623
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction & aims: Candida albicans (C. alb) is a fungal commensal of the GI tract. The surface of C. alb is composed mostly of glycans and their improper recognition is speculated as a trigger of chronic inflammation. Indeed, antibodies against surface glycans such as ASCA and ALCA are elevated in IBD. We hypothesized that glycans from C. alb modulate immune responses. Thus, our aim was to examine the effect of C. alb on T cell and intestinal epithelial cell (IECs) function and compare it to synthetic glycans. Methods & results: Exposure of naive PBMCs to heat killed C. alb yeast or hyphae activated T cells (…
Schlagworte
Apoptosis
Candida albicans
Candida
Antibodies
Annexin V
Zeitschrift für Gastroenterologie
