The role of RORγt in T17-mediated allo- and autoimmunity

Introduction: IL-17-producing T cells (T17) play a major role in allograft rejection and beyond, as T17 cells in Th1-deficient mice mediate pro-inflammatory immune responses resulting in accelerated allograft rejection and autoimmunity. However, the mechanisms underlying T17-mediated immune responses in transplantation and autoimmunity are poorly understood, particularly with respect to regulation by the hallmark T17 transcription factor RORγt. Specific aims and methods: To precisely explore the role of RORγt in T17 alloimmunity in the absence of Th1, we created RORγt reporter and knockout mice on a T-bet-defici…