Ablation of Cdk2 uncovers kinase-independent functions of Cyclin E1 for liver regeneration in mice
W Hu, YA Nevzorova, JR Nowak, U Haas, N Moro, Y Geng, P Sicinski, M Barbacid, C Trautwein, C Liedtke · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
The liver has a strong capacity to regenerate in response to injury. In this process, remnant hepatocytes leave their quiescent state, re-enter the cell cycle and proliferate until liver mass and functions are restored. In vitro studies have indicated that cyclin-dependent kinase 2 (Cdk2) is an important cell cycle mediator driving initiation and progression of DNA-synthesis via complex formation with E- and A-type cyclins respectively. The aim of the current study was to evaluate the role of Cdk2 in hepatocyte proliferation. Hepatocyte-specific Cdk2 deleted mice (Cdk2Δhepa) and wild type (WT) controls were subj…
